Integrity Wellness MD offers a compassionate and understanding environment for women struggling with PMDD to ask the difficult questions and receive advanced treatment for improving their quality of life.
Premenstrual syndrome is a common hormonal disorder that makes its presence known in the few days leading up to a period and lasts until a few days into the bleeding. However, there is a lesser known disruption that takes place during the luteal phase. It’s a rare occurrence, only affecting between 5-8% of women and its symptoms are much more severe. This is called Premenstrual Dysphoric Disorder or PMDD.
PMDD is primarily considered a mood disorder and has only recently been added to the Diagnostic and Statistical Manual of Mental Disorders in 2013. PMDD occurs when a woman is much more sensitive to the hormonal fluctuations of estrogen and progesterone and become unable to regulate their emotions, so much so that it becomes an impairment to their daily lifestyle.
Integrity Wellness MD of Charlotte can help you alleviate symptoms of PMDD. Don’t suffer alone, call (980) 701-9228 today and discover how we can help you with natural bioidentical hormone replacement therapy.

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Experience the comprehensive benefits of functional medicine at Integrity Wellness MD, where our focus is on personalized treatment strategies tailored to your unique health needs. Our approach combines advanced hormone testing, bioidentical hormone therapy, targeted supplementation, and lifestyle modifications to help you achieve optimal health and vitality. Take advantage of our extensive resources, including a free health quiz, detailed guides, engaging webinars, and schedule a personal call with Dr. Gretchen Reis. Discover how our precise, targeted approaches can enhance your overall health and vitality, even in cases where conventional tests may fail to reveal the full picture. Begin your journey to lasting wellness with us today!
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Diagnosing Premenstrual Dysphoric Disorder
Diagnosing PMDD can be a difficult process, and there are no physical tests that produce the ‘yes’ or ‘no’ answer that the patient and doctor are looking for. Typically, your doctor will have you journal your symptoms for a number of months and, in order to be diagnosed with PMDD, 5 or more of the following symptoms must be present most of the time:
How is PMDD treated?
While exercise, a healthy diet, quitting smoking, and stress management are always beneficial and will promote across-the-board health, PMDD’s symptoms are sinister in their ability to undermine and divert your efforts.
Many doctors will prescribe birth-control pills, but these will only alleviate the symptoms, not to mention the trial and error of finding the right pill. There are often side effects with birth-control such as acne, depression, blood clotting, nausea, and more. Also, this approach can derail a woman’s family aspirations.
PMDD is ultimately a chemical imbalance and throwing more lab-synthesized unnatural and harsh compounds at it is more akin to throwing gasoline on a dumpster fire.
For these reasons, our women’s health and hormone experts offer Charlotte women natural and safe Bioidentical Hormone Replacement Therapies. Bioidentical Hormones are identical to the hormones present in your body, which means no harsh or harmful side effects. Our providers will develop a customized plan that will balance your progesterone and estrogen, preventing your serotonin from the supreme drop that leads to the severe symptoms of PMDD.
Integrity Wellness MD providers understands the intricacies of Premenstrual Dysphoric Disorder and is determined to help you understand what is happening in your body, while offering a safe and compassionate environment for you to ask the difficult questions.
Frequently Asked Questions About PMDD
How Are PMS and PMDD Different?
Premenstrual syndrome affects around 75% of women in their childbearing years, but only 1 in 10 women experience the more severe symptoms of PMDD. So luckily, it’s less likely that a woman is suffering from PMDD, but there are some key differences in their affect on afflicted women:
Both typically cause symptoms in the one to two weeks before your period, and improve within a few days of your period starting.
The biggest difference is the severity and type of symptoms, PMS typically allows a woman to still function within a fairly normal margin of her everyday life, she may still experience the bloating and nausea, even depression and irritability, but her job and relationships are often unaffected and she is able to push through. PMS is primarily physical symptoms, whereas PMDD is considered a mood disorder.
PMDD, however, creates a major disruption in the way a woman thinks, feels, and acts. The same symptoms of PMS are present, but in greater severity, often causing more trouble in daily life. In the thick of PMDD symptoms, a woman can exhibit frequent and volatile moods that may present themselves as rage, anxiety, depression, and/or sensitivity that leads to tension and difficulty maintaining their lifestyle.
How Is PMDD Diagnosed?
Your doctor will ask you to maintain a tracker chart of your symptoms for a number of months. PMDD has 11 symptoms that it checks for. According to the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th Edition), at least 5 of the symptoms must be present consistently in order for a woman to be diagnosed with PMDD.
The tracked symptoms will be:
(One of these first four symptoms must be present to be considered PMDD)
- Depression: feelings of guilt, worthlessness, hopelessness
- Anxiety: feeling tense, on edge, unable to relax
- Mood Swings: rejection sensitivity, suddenly tearful, sensitive to feedback
- Anger: feeling irritable or easy to snap, marked by increasing conflicts with peers
- Disinterest: sudden and inexplicable apathy towards activities you loved only days ago
- Difficulty Concentrating: brain fog or inability to put your mind to the task at hand
- Fatigue: a general feeling of lethargy or physical exhaustion
- Appetite Change: bouts of binge eating or sudden shifts from a healthy diet to one riddled with unhealthy and uncontrollable cravings
- Sleeping Changes: inability to fall asleep or stay asleep at bedtime, needing to take naps during the day or sleep in after your alarm has rung
- Out of Control: feeling overwhelmed with the world, there is suddenly not enough time to do everything that is necessary
- Physical Symptoms: bloating, headaches and migraines, cramps, back pain, tension in parts of your body
After your doctor has reviewed your chart with you, they will be able to make a diagnosis and begin treatment.
What causes PMDD?
There is no known cause for PMDD, however a study by the National Institutes of Health in 2017 discovered that diagnosed women are more sensitive to the fluctuations in estrogen and progesterone.
It is also believed that women with PMDD experience a more dramatic serotonin drop, which is associated with changes in mood, cognition, and cravings.
What are the risk factors for PMDD?
A woman who has a personal or family history of mood disorders may be more likely to develop PMDD. There are also genetic factors that disrupt hormonal balances. Smoking and high levels of stress can also play a role in hormonal fluctuation.
What are the long term risks of PMDD?
PMDD is still widely unheard of and, while many women are safe, an overwhelming number of women who have PMDD are unaware of what is causing their difficulties. Because of this, many women are unable to seek treatment, and the depression and hopelessness can lead to more severe measures.
Left untreated, PMDD can lead to long term depression and risk of suicide, as well as social and personal relationship losses and conflicts. For aspiring and expecting mothers, PMDD can later become very severe postpartum depression.
Bioidentical Hormone Replacement Treatment Protocols
Oral Hormone Supplements:
Hormone therapy can help restore normal hormone function and health and restoring those primary functions can be as easy as taking a couple of extra supplements in your day. Oral Hormone Supplements can be in the form of pills, soft gel capsules, powders, and liquids and can be a wonderful and simple addition to your health and upkeep routines.
Transdermal Hormone Patches and Creams:
Skin is the largest organ of the human body and can absorb all manner of things it encounters, from cosmetics to the plastics from the bottles those cosmetics are stored in. Hormones can also be absorbed this way and, by placing them directly on the skin as a cream or on a worn patch, it allows those hormones to be absorbed directly into the systemic circulation system (the system that carries blood through your arteries, veins, and capillaries), which means less work for your liver. From there, it’s simply a matter of the hormones working through the system to give that healthy, natural boost and amplify your wellbeing!
Hormone Injections:
Receiving much needed hormone therapy can be as easy as a quick injection. These injections are most often administered to the upper thigh or buttocks at consistent increments, usually about once or twice a week. Because of their quick metabolic absorption rate and frequency, they are most quickly and easily adjusted to make sure they are fitting the needs and balances of the individual.
Implanted Hormone Pellet Therapy:
The procedure for implanting hormone pellets is actually quite quick and very simple. After a local anesthesia is applied to the upper buttocks area, a small incision is made and a pellet the size of a grain of rice is inserted, then is covered with a small bandage. This procedure takes about 15 minutes and lasts for 3 to 4 months. While they are in your system, implanted pellets slowly release those helpful hormones in response to your natural stressors, keeping you steady and level for longer periods.







