What Men Need to Know About Testosterone Replacement Therapy (TRT)

Testosterone is a steroid hormone that is primarily produced in the testicles of males and in smaller amounts by the ovaries of females. It plays a vital role in the development of male reproductive tissues, including the testes and prostate, as well as the growth and maintenance of male secondary sexual characteristics, such as muscle mass and strength, body hair, and a deep voice. Testosterone also plays a role in sperm production, sexual function, libido, and bone density. In females, testosterone is produced in smaller amounts by the ovaries and helps regulate the menstrual cycle, bone density, and sex drive.

Low testosterone levels (hypogonadism) can affect men of all ages, not just those who are older. Symptoms such as decreased libido, fatigue, reduced facial and body hair growth, and muscle and bone loss can be a sign of low testosterone. If you’re experiencing these symptoms, testosterone replacement therapy  may be a solution. However, with various administration methods available, it can be overwhelming to know which one is best for you. Oral testosterone preparations are generally not used because they can cause liver problems and do not keep testosterone levels steady. Other preparations include gel, creams, injections, patches, cheek tablet, nasal spray, and implantable pellets.

What Are Testosterone pellets?

Testosterone pellets are a type of hormone therapy that involve small, rice-sized pellets being inserted under the skin by a medical professional. They release a consistent, low dose of testosterone over a period of 4 to 6 months, providing a steady supply of the hormone to the individual.


Dr. Reis genuinely believes that medicine should heal ailments for longer periods of time as opposed to a temporary fix. She encourages her patients to lead an overall healthy life to prevent disease and reduce the number of pills taken. Because of her attitude and approach, you can be assured that you are in the best care.

Increased Testosterone Levels May Benefit  Men*

One of the most notable benefits is an increase in muscle strength and mass. Testosterone plays a vital role in the growth and maintenance of muscle tissue, and increasing levels can help men to build and maintain lean muscle mass. This can improve physical fitness and overall body composition.

Testosterone also helps to regulate fat distribution, which can lead to a decrease in body fat and an increase in lean muscle mass. This can help to improve overall body composition and reduce the risk of obesity-related health issues.

Increasing testosterone is the improvement of bone density. Testosterone plays a key role in the maintenance of bone density, and increasing levels can help to prevent osteoporosis and reduce the risk of fractures.

Facial and body hair growth is also regulated by testosterone, so increasing levels can help to improve the appearance of facial hair and body hair.

Testosterone also helps to improve mood and energy levels, making men feel more alert and energetic. It also helps to improve sleep quality, making men feel more rested. Testosterone is also important for maintaining a healthy sex drive, and for sperm production, which is important for fertility.

Testosterone has anti-inflammatory effects, which can help to decrease inflammation in the body and lower cholesterol levels. It also plays a role in red blood cell production, which can help to improve oxygenation in the body and increase energy levels.

How Quickly Does TRT Start Working?

The effects of TRT are gradual. Many men begin to experience the benefits of the treatment within a few weeks of starting it, achieving their wellness goals within four to six months.

Research** showed that improvements were achieved generally. Effects on sexual interest have been seen after 3 weeks and improvement in mood was observed within 3-6 weeks. The effects on inflammation were observed within 3-12 weeks. Changes in body fat mass and muscle strength took a bit longer and were seen within 12-16 weeks, while it took at least 6 months to detect changes in bone density. However, improvements in quality of life were noticed within 3-4 weeks, but full benefits take longer. 

Once You Start Testosterone Therapy Can You Stop?

TRT requires ongoing treatment. If treatment is discontinued, testosterone levels will decrease. If testosterone therapy is providing desired benefits such as improved sexual function, muscle mass, bone density, and overall well-being, it can be continued as long as both the individual and their healthcare provider agree.

Whether you are looking for primary care or BHRT and an integrative medicine approach, Dr. Gretchen Reis and her team are dedicated to addressing your wellness concerns with targeted treatment plans designed to achieve and maintain optimal health.

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** Eur J Endocrinol. 2011 Nov; 165(5): 675–685.